I've tried to share this with Gamefaqs and Reddit but both are pretty less than pleased about someone doing this for whatever reason. "Stop being so boring, man up and remove the debuffs" and "or you can just use X to kill them in one hit...?". It can get a bit depressing at times haha. I'm currently stuck at floor 108 where I have to face two of the harder bosses at the same time, while each hit of theirs paralyzes me (so if I survive, I'll die anyway), their attacks deal 20% damage through my block, there are unremovable yokai pools everywhere (reduced ki regeneration when you're in them) and they have skeleton soldiers with ranged weapons that spawn every ten seconds (max of 2 on screen). So it is...hard haha!
Here are some examples of previous fights:
Maria (is she hits you your movement speed is slowed by 50%, you are always on fire, ranged weapons don't work, there are zones of fire)
Tachibana (removes all buffs when he hits you, attacks through block, reinforcements, yokai pools)
It's really nice that Team Ninja added these optional challenges, and it's a darn shame nobody is doing them as they are really just upright, no holds bared pain in your ass. Love it!